Unveiling the Miraculous Benefits of NAD+:

A Functional Medicine Perspective

NAD+(nicotinamide adenine dinucleotide) helps to maintain DNA integrity and ensure proper cell function. NAD+ comes from kynuremime pathway and Preiss-Handler pathway. 

In this pathway, NAD+ also can be converted from Nicotinamide ribose (NR) and Nicotinamide mononucleotide (NMN). NAD+ precursor can also be produced by bacterial microflora in the intestines or saliva. 

Benefits of NAD+:

1. Enhanced Cellular Energy Production:

NAD+ is essential for generating ATP, the primary energy currency of cells. Increased NAD+ levels can boost cellular energy production, promoting overall vitality and performance.

2. Improved Mitochondrial Function:

Mitochondria, the powerhouses of cells, rely on NAD+ for proper functioning. NAD+ supplementation can improve mitochondrial health and efficiency, leading to enhanced energy levels and cellular function.

3. Anti-Aging Properties:

NAD+ levels decline as we age, contributing to various age-related conditions. By boosting NAD+ levels, you can promote healthy aging and reduce the risk of age-related diseases.

4. DNA Repair and Protection:

NAD+ is crucial for DNA repair mechanisms and maintaining genomic stability. Supplementing with NAD+ can help protect your DNA from damage and promote optimal cellular health.

5. Supports Cognitive Function:

NAD+ is essential for proper brain function and neurotransmitter production. Increased NAD+ levels can support cognitive performance, memory, and overall brain health.

6. Reduced Inflammation and Oxidative Stress:

NAD+ plays a vital role in regulating inflammation and the body’s antioxidant defenses. By increasing NAD+ levels, you can reduce inflammation and oxidative stress, thereby promoting overall health and wellbeing.

7. Enhanced Physical Performance:

NAD+ is involved in the activation of sirtuins, a family of proteins that regulate cellular processes such as inflammation, stress resistance, and muscle tissue repair. Increased NAD+ levels can promote muscle recovery and maintenance, leading to improved physical performance. NAD+ can also improve oxygen utilization in muscles, enhancing aerobic capacity and physical endurance.

8. Supports Cardiovascular Health:

NAD+ is involved in the production of nitric oxide (NO), a molecule that helps relax blood vessels and maintain proper endothelial function. By supporting NO production, NAD+ helps promote healthy blood flow and overall cardiovascular health.

Apart from that, NAD+ has an anti-inflammatory effect. Endothelial inflammation is the key to cardiovascular diseases. Preventing inflammation prevents cardiovascular diseases, especially atherosclerosis. 

9. Improved Metabolic Health:

NAD+ plays a critical role in regulating glucose metabolism by participating in the glycolysis and citric acid cycle that helps to break down glucose to produce ATP and other energy-rich molecules. By regulating blood sugar levels, NAD+ reduced the risk of insulin resistance and T2DM.

NAD+ is also involved in the breakdown of fatty acids through beta oxidation which occurs in mitochondria. This helps the body to generate energy from stored fats and maintain healthy body weight.

However, NAD+ level declines with age as our bodies are using up NAD+ as we age and we do not have adequate supply of NAD+ along the way. Low level of NAD+ affect the performance of Sirtuins(SIRTs) and poly(ADP-ribose) (PARPs), the key component for DNA repair, gene expression and cell death, which in turn contributes to decline in cell function and aging.

How to increase NAD+ levels?

1. Eating healthy 

a) Getting vitamin B3 from natural sources

b) Small amount of NMN is available in vegetable like broccoli, cucumber and cabbage. 

c) Intermittent fasting creates a mild stress which stimulates production of NAD+

2. Exercise

3. INFRARED Sauna 

4. NAD+ precursors

a) Supplementing with NMN and NR can successfully boost body NAD+ level.

Functional medicine Malaysia doctor

Dr. Shirley Koeh
15 April 2023

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